Dermoscopy has been used to diagnose non-melanocytic tumors. The significance of the disease depends on the extent of the lesions, potential for functional disability or cosmetic disfigurement, and presence or Abstract. In our patient, the vitiligo lesion was clearly identifiable, since its achromic macular aspect with jagged border, while the morphea lesion could be confused with other sclerotic conditions, including lichen sclerosus, radiodermatitis, and intralesional steroid-induced Morphea, also known as localized scleroderma, is a rare fibrosing disorder of the skin and underlying tissues. Both structures are similar, however, the white fibrotic beams tend to be smaller, more opaque with less defined margins, compared to the white Jan 10, 2022 · Skin biopsy is an important tool in the diagnosis of morphea. in a 46-year-old man who presented with an alopecic patch on the occipital scalp, which, at histopathological examination, revealed an intense perineural lymphocytic infiltrate and was considered a clue for diagnosis. Feb 17, 2020 · The diagnosis of morphea is typically made by the presence of clinical findings, although histopathology and radiologic imaging can be used to assist with diagnosis for patients with atypical Mar 16, 2017 · The differential diagnosis of EF consists of morphea, SSc, scleroderma-like conditions, and miscellaneous diseases characterized by signs of inflammation and peripheral eosinophilia. Dec 14, 2012 · The main differential diagnoses are lichen planus (LP), lichen simplex chronicus, vitiligo, immunobullous disorders such as mucous membrane pemphigoid and vulvar or penile intraepithelial neoplasia [11, 54]. Case Report: We present the case of a 33-year-old man with a single cicatricial alopecic patch of the scalp. The compatiblewithscleroderma(morphea). At the ageof 9 months, treatment with oral Differential diagnosis includes classic morphea, lichen sclerosus (LS), and idiopathic atrophoderma ofPasiniandPierini(IAPP). Dyslipidemia was the most common comorbidity (30%), followed by diabetes (15%) and hypertension (15%). The differential diagnosis for lymphocytic lobular panniculitides is broad; however Jan 15, 2022 · Moreover, this method enables differential diagnosis, especially with extragenital variants of lichen sclerosus [16,18,21,22]. The underlying pathogenesis of morphea is not completely understood at this time, but ultimately results in an imbalance of collagen production and destruction. The patient was successfully treated with mometasone ointment 0. , linear Mar 9, 2021 · In this paper, we discuss differential diagnoses to be considered and this new promising treatment option based on a case review of the literature. INTRODUCTION. Bone marrow abnormalities mimicking those in morphea are expected mainly in patients with venous stasis, chronic recurrent multifocal osteomyelitis, shin splint, or diverse Mar 16, 2017 · The differential diagnosis of EF consists of morphea, SSc, scleroderma-like conditions, and miscellaneous diseases characterized by signs of inflammation and peripheral eosinophilia. 1). A careful clinical assessment that includes an evaluation of patient risk factors, lesion distribution, and associated clinical findings (eg, ulceration, sclerosis, atrophy Sep 6, 2023 · Carpal tunnel syndrome – in morphea at the wrist; Chronic ulcers or squamous cell carcinoma – in pansclerotic morphea; Pediatric patient considerations: In children, morphea is observed in a 2-3:1 female-male ratio, with the mean age of onset ranging from 7-10 years. Morphea is distinct from systemic sclerosis (scleroderma), an autoimmune connective tissue disorder characterized by acral or diffuse cutaneous sclerosis and frequent systemic manifestations. Nodular BCC may be confused with trichoblastoma or trichoepithelioma. Differential diagnosis of both conditions is summarized in Table 2. The main clinical, trichoscopic, and histopathological findings are described. The differential diagnosis of LEP and deep morphea is discussed. Morphea, or localized scleroderma, is a rare disease of the connective tissue that manifests itself with localized sclerosis of the skin and, in some cases, with extracutaneous manifestations. A punch biopsy of cutaneous lesions showed a thick hyperkeratotic scale and an atrophic epidermis with flattening of the rete ridges. Jul 4, 2022 · Circumscribed morphea of the scalp is a clinical entity first described by Saceda-Corralo et al. Front. Differentiation between morphea and EF is mainly based on the characteristic distribution of cutaneous sclerosis in different morphea subtypes (i. This is likely due to use of different classification systems. Apr 18, 2024 · Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft tissue sarcoma primarily found on the trunk and proximal extremities that typically appears as a slowly progressing, firm, violet-red, or blue plaque. Linear patches, especially on the arms or legs and possibly the forehead or scalp. In the early inflammatory phase of limited LS (morphea), which starts with patchy, moderately inflamed, slowly extending Aug 21, 2019 · Dermoscopy is a non-invasive technique for diagnosing skin lesions, which aids in the differentiation between benign and malignant alterations. Patients with morphea commonly have systemic symptoms, such as malaise, fatigue, arthralgias Features, Differential Diagnoses and Modern Treatment Concepts. A variant of morphea with extensive subcutaneous involvement has been termed morphea profunda. The median age of onset in children is between 5 and 10 years old. Differential diagnosis is complicated by the fact that several pseudosclerodermas can imitate scleroderma beyond the symptom of sclerosis of the skin, and that, in rare cases, visceral scleroderma can occur without sclerosis of the skin [4]. The approach to the patient with hair or nail abnormalities or oral lesions is also discussed separately. Given the various disease phases und clinical manifestations, there is a wide variety of possible differential diagnoses to be taken into account 40. Jan 1, 2014 · The diagnosis is usually made based on characteristic clinical features with biopsy to exclude other entities on the differential diagnosis. Patches that gradually develop a lighter or whitish center. Morphea of the breast is an uncom … May 24, 2010 · Request PDF | Postirradiation Morphea: A Case Report With a Review of the Literature and Summary of the Clinicopathologic Differential Diagnosis | Postirradiation morphea is a rare complication of The remainder of her skin exam was unremarkable. Morphea, also known as localized scleroderma, is an idiopathic, inflammatory disorder that causes sclerotic changes in the skin. Jul 1, 2018 · Because the morphology of morphea lesions can vary depending on the stage of disease progression, it is important to consider a variety of possibilities in the differential diagnosis of a lesion of morphea (Table). e. The exact cause of morphea is unknown. They include: Reddish or purplish oval patches of skin, often on the belly, chest or back. The heterogeneity of various forms of SSc as well as the multitude of scleroderma-like diseases routinely Oct 1, 2021 · The differential diagnosis of the skin patches included morphea and extragenital LSA, due to their clinical morphology and distribution and to the association with anogenital lesions . Although morphea lesions show a more prominent inflammatory infiltrate than do scleroderma lesions, the distinction requires clinicopathologic correlation. Histological examination can help characterize the degree of inflammation and depth of sclerosis, and it can help rule out other entities in the differential diagnosis (Table 5. Information Center. Morphea is relatively uncommon and women are affected about three times as often as Morphea is differentiated from systemic sclerosis (scleroderma) based … This article outlines the epidemiology, pathogenesis, clinical presentation, diagnosis, and treatment of childhood morphea. There is also information about the possibility of using dermoscopy to assess the efficacy of the treatment of morphea . However, it is considered an autoimmune disease and is associated with various predisposing factors. In most cases, careful history aimed at ascertainment of the evolution of the lesions, accompanying symptoms, and past medical history, along with total body skin and musculoskeletal examination, is sufficient. Your doctor might also take a small sample of your skin (skin biopsy) for examination in a laboratory. Aug 7, 2023 · Point of Care - Clinical decision support for Morphea. Mar 9, 2020 · The differential diagnosis depends on the stage of disease and the type of morphea. Morphea-like BCC may be confused with a plaque GARD Genetic and Rare Diseases. Eosinophilia-Myalgia Syndrome. Consequently, pathology reports should include descriptions of these findings. Morphea is a localized form of scleroderma and affects primarily just the skin. Scleroderma. [ 45 ] Jan 11, 2013 · Differential Diagnosis and Unusual Presentations. Local tissue trauma is a known precipitating factor for morphea lesions, and patients may confuse morphea lesions with trauma-induced . Treatment. It often only affects the outer layer of skin but sometimes leads to more serious issues due to the involvement of deeper parts of the body. in 1854, where females demonstrated a higher incidence than males (ratio F : M 4 : 1) [ 3 ]. The diagnosis of localized Early stage diagnosis is followed, in many cases, of conservative surgery and local radiotherapy. We present a review of the current Dec 27, 2013 · Morphea (localized scleroderma) is a rare fibrosing disorder of the skin and underlying tissues characterized by skin thickening and hardening due to increased collagen deposition. Sep 20, 2023 · This can be a rationale for classifying the morphea subtypes based on clinical and histopathological characteristics and may be helpful in the differential diagnosis of GM and SSc. Jul 11, 2023 · Extragenital lichen sclerosus refers to lichen sclerosus in sites other than the anogenital area. Another rare variant on the face is Parry Romberg’s syndrome, which is characterized by a progressive atrophy of adipose tissue, muscles, cartilage and bones that is responsible for a characteristic facial May 18, 2021 · The paper attempts to present the debatable aspects regarding nomenclature, classification, diagnosis and treatment of morphea. However morphea can occur in a generalized form as well as guttate, nodular, subcutaneous and linear forms. The absence of Raynaud’s phenomenon, nail-fold-capillary changes, sclerodactyly, hallmark systemic sclerosis antibodies, and visceral organ involvement point to a diagnosis of morphea over SSc. While in LS white-yellowish patches are the most common dermoscopy feature, morphea presents white fibrotic beams. Signs and symptoms of morphea vary depending on the type and stage of the condition. A third biopsy revealed mild hyperkeratosis in the epidermis and possible mild sclerosis of the dermis with dermal inflammation. 80 (6):1658-1663. Eosinophilic fasciitis (EF), also called Shulman syndrome, is a rare, localized fibrosing disorder of the fascia. Coping. Jan 1, 2009 · A superior method for considering diagnostic entities with subtle histologic changes is to develop a systematic plan for reviewing all skin biopsies. Workup. Conclusion: We suggest considering scalp morphea in the differential diagnosis of mono-lesional cicatricial alopecia involving the scalp. Keywords: IL-6; case report; pansclerotic morphea; scleroderma; stiff skin; tocilizumab. Morphea is classified into circumscribed, generalized, linear, and pansclerotic subtypes according to the clinical presentation and depth of tissue Gadodiamide-associated nephrogenic systemic fibrosis has recently been described, and this disorder should also now be included among the differential diagnoses of morphea . In the early disease stages, morphea can be challenging to differentiate from many inflammatory dermatoses, such as lichen sclerosus, granuloma annulare, erythema chronicum migrants or drug-induced dermatitis. Residents should be involved in reviewing outside records, compiling outside clinical data, interviewing and examining the patient, efficiently presenting the patient by including pertinent information and leaving out extraneous information, and developing a differential diagnosis with supporting and refuting facts for each diagnosis. 1 Morphea is more common in whites, although population-based studies have not verified this observation. Aug 7, 2023 · Differential Diagnosis. A skin biopsy for histopatho logical evaluation is usually reserved . Nov 8, 2016 · Differential Diagnosis of Morphea Many morphea patients experience delay in diagnosis and treatment because providers fail to recognize this relatively rare disease [ 80 ]. Jun 17, 2020 · Next: Imaging Studies. Early stage diagnosis is followed, in many cases, of conservative surgery and local radiotherapy. 656407 The final diagnosis was pansclerotic morphea, based on Because the morphology of morphea lesions can vary depending on the stage of disease progression, it is important to consider a variety of possibilities in the differential diagnosis of a lesion of morphea . Necrobiosis lipoidica is three times more common in females than in males, and usually develops in young and middle-aged adults. Treatment and management. Aug 25, 2022 · Diagnosis. Mar 9, 2021 · The differential diagnoses include a generalized presentation of localized scleroderma (especially the deep variant of pansclerotic morphea (PSM)], systemic sclerosis, scleroderma-like disorders such as scleredema and eosinophilic fasciitis, or stiff skin disease. Two biopsies of the right forearm showed normal skin. Oct 5, 2021 · Morphea, a localized form of scleroderma, is a chronic inflammatory autoimmune disease of the skin. 4 Onset before age 2 years represents 11% of pediatric-onset cases, but vitiligo presenting at birth or in older adults is exceedingly rare. IAPP commonly coexists with morphea and is believed to be an abortive scleroderma in which sclerosis fails to form. A final diagnosis of localized scleroderma was made. Contact a GARD Information Specialist to receive the individualized support you may need. org May 31, 2019 · Morphea, also known as localized scleroderma, is an idiopathic, inflammatory disorder that causes sclerotic changes in the skin. Other conditions confused with morphoea en coup de sabre may include: Traumatic injury; A birthmark; Birth trauma; Bandlike melasma; Linear cutaneous lupus erythematosus Mar 13, 2024 · The differential diagnosis of BCC includes adnexal tumors with follicular, sweat gland, or sebaceous differentiation and certain types of SCC. Skin biopsy techniques are discussed separately. 2021. It was first described by Addison et al. Your doctor may diagnose morphea by examining the affected skin and asking about your signs and symptoms. Toxic Oil Syndrome. Jan 27, 2016 · Differential diagnosis – differentiation from other fibrotic diseases. Some of the entities in the differential diagnosis above often manifest with a sclerodermoid (ie, diffuse sclerosis) rather than morpheaform (ie, discrete areas of sclerosis) morphology. Linear morphea is the most common subtype in childhood. [2] in a 46-year-old man who presented with an alopecic patch on the occipital scalp, which, at histopathological examination, revealed an intense perineural lymphocytic infiltrate and was considered a clue for diagnosis. Nov 20, 2021 · The diagnosis of morphea is usually based on clinical data, although histopathological confirmation is sometimes required [1,3,4,5,6]. Differential diagnosis. Systematically review each anatomic layer of the skin (see Chapter 1) Specifically detect subtle lesions that may be present at each level. In clinically inconclusive cases, a histologic examination is advisable and might close the gap, but should never be interpreted in isolation. Diagnosis. However, there is still a lack of information on whether there are certain dermoscopic Thus, biopsy in morphea may not just be indicated for diagnosis, but also assessment. Eosinophilia. Introduction, Etiology, Epidemiology, Pathophysiology, Histopathology, History and Physical, Evaluation, Treatment / Management, Differential Diagnosis, Toxicity and Adverse Effect Management, Prognosis, Complications, Deterrence and Patient Education, Enhancing Healthcare Team Outcomes Oct 24, 2007 · Differential diagnosis is complicated by the fact that several pseudosclerodermas can imitate scleroderma beyond the symptom of sclerosis of the skin, and that, in rare cases, visceral scleroderma can occur without sclerosis of the skin . The differential diagnosis includes systemic sclerosis: Generalised plaque morphoea - Raynaud's phenomenon is uncommon, the trunk is the predominant site, the condition usually improves over time Systemic sclerosis - Raynaud's phenomenon affects nearly all patients, the face and hands are the predominant sites, the condition is progressive Jul 4, 2022 · Circumscribed morphea of the scalp is a clinical entity first described by Saceda-Corralo et al. Breast cancer is the most common cancer in women of developed countries. It most commonly presents in association with classic chronic cutaneous lesions of discoid lupus erythematosus; however, such lesions, as well as a clinical history of lupus erythematosus, may be lacking. [QxMD MEDLINE Link] . There is also information about the possibility of using dermoscopy to assess the efficacy of the treatment of morphea [ 15 ]. 7 per 100,000 with a female-to-male ratio of 2 to 3:1. Patients with morphea commonly have systemic symptoms, such as malaise, fatigue, arthralgias, and myalgias, as well as positive autoantibody Aug 25, 2022 · Diagnosis. Morphea of the breast is an uncommon skin condition and has been described after radiotherapy. Morphea, also sometimes called “localized scleroderma,” is a rare autoimmune disorder that causes skin thickening, hardening, and color changes. Color Doppler Ultrasound has been reported as a reliable tool to assess the activity of the disease. Its etiology is not fully understood, but it is believed that there is genetic predisposition, in addition to environmental triggering factors. May 30, 2023 · The predominant form of scleroderma in children is juvenile localized scleroderma (JLS), also sometimes called morphea, which principally involves the skin, fascia, muscle, and bone [ 1-3 ]. This can reveal changes in your skin, such as thickening of a protein (collagen) in the second layer of skin (dermis). Jul 3, 2023 · Morphea lesions were examined and compared blindly with 17 control plaques in 16 patients with skin diseases with differential diagnosis of LoS. Morphea is a form of scleroderma that mainly involves isolated patches of hardened skin on the face, hands, and feet, or anywhere else on the body, usually with no internal organ involvement. 2-5 The relative frequency of the different subtypes varies between studies. Morphea has an estimated incidence of 2. Strategy. The present guideline focuses on characteristic clinical and histopathological features, diagnostic scores and the serum autoantibodies most useful for differential diagnosis. Five patients were reevaluated clinically and with ultrasound imaging 12–18 months after the first examination Abstract. 11–65% of patients with necrobiosis lipoidica have diabetes or prediabetes. The development of morphea can be insidious and subtle, and initial misdiagnosis, particularly by nondermatologists, occurs frequently [ 80 ]. The limitations of the current study include its retrospective, single-centre design; small sample size; lack of disease activity score; and limited ethnic diversity. IAPP is histologically characterized with variable epidermal atrophy: decreased thickness with flattening The reported case demonstrates the difficulties in establishing the diagnosis of LEP in patients who present with subcutaneous disease, morphea-like lesions and who do not have other clinical or laboratory evidence of lupus erythematosus. 2019 Jun. (See Sep 1, 2020 · The diagnosis of morphea can typically be made based on clinical findings, however biopsy of the lesions and imaging can help confirm the diagnosis or exclude other diagnoses. The differential diagnosis of morphea is extensive and provided in Table 2. Also known as localized scleroderma, morphea is a fibrosing disorder of the skin and subcutaneous tissues. [1] However, in Deep Morphea inflammation and sclerosis can be found in the deep dermis, panniculus, fascia, superficial muscle and bone. It is vital to differentiate morphea from systemic sclerosis due to its systemic organ involvement and bad prognosis with delay in diagnosis. Jan 30, 2022 · Moreover, this method enables differential diagnosis, especially with extragenital variants of lichen sclerosus [16,18,21,22]. IAPPcommonlycoexists with morphea and is believed to be an abortive scleroderma in which sclerosis fails to form. Lesions are usually limited and most commonly just one lesion is found. Differentiating these disorders is not always straightforward. Jul 28, 2021 · Treatment of morphea with hydroxychloroquine: A retrospective review of 84 patients at Mayo Clinic, 1996-2013. One may take into consideration tinea nigra, clinically characterized by brownish macules localized on palms and soles, and the hyperchromic form of pityriasis versicolor. Morphea is differentiated from systemic sclerosis based on the absence of sclerodactyly, Raynaud phenomenon, and nailfold capillary changes. Recently, vascular morphology has been identified as an important criteria in dermoscopic diagnosis when assessing non-melanocytic tumors. Available toll-free Monday through Friday from 12 pm to 6 pm Eastern Time. Results were also compared with a normal control group. Localized Fibrosing Disorders - Linear Scleroderma, Morphea, and Regional Fibrosis. Apr 24, 2024 · Differential Diagnosis of Morphea Many morphea patients experience a delay in the diagnosis and treatment because providers fail to recognize this relatively rare disease [ 80 ]. Feb 13, 2023 · 6. Laboratory tests used to refine or confirm a dermatologic diagnosis are discussed in relevant topics. 1%. Clinical images showing (a) atrophic and slightly Jan 3, 2024 · Morphea scleroderma is a skin condition characterized by hardened, discolored, and thickened patches of skin on various areas of the body without internal organ involvement. Sep 25, 2020 · Differential Diagnoses. This treatment reduces loco-regional recurrences but may be accompanied by local complications. 1% of patients with diabetes will develop necrobiosis lipoidica. Finding the right health care provider or getting the correct diagnosis may prove challenging. The various clinical subtypes of LS require different approaches to evaluation and treatment. Systemic Sclerosis. Because DFSP is a slow-growing tumor, the diagnosis is often delayed for months to years. The findings of this biopsy were considered non-specific, with quiescent morphea on the differential diagnosis. Extragenital involvement typically presents as porcelain-white, hypopigmented, or hyperpigmented, atrophic plaques ( picture 1A-E) and may accompany genital lichen sclerosus, occur alone, or overlie lesions of morphea (localized scleroderma). Most cases of DFSP are associated with a t(17;22) (q22;q13) translocation, generating the fusion Feb 2, 2021 · Differential diagnosis includes classic morphea, lichen sclerosus (LS), and idiopathic atrophoderma of Pasini and Pierini (IAPP). Based on the clinical features and histological pattern, a diagnosis of congenital localized scleroderma (CLS) was made. All differential diagnoses that should be taken into consideration when diagnosing morphea are listed in Table 3. It can occur in both type 1 and type 2 diabetes mellitus. Autoimmune diseases occur when the immune system, which normally protects us from bacteria, viruses, and fungi, mistakenly attacks a person’s own body. A broad differential diagnosis is therefore required when evaluating a patient with increased thickness of the skin. In addition, current strategies in the first- and advanced-line therapy of sclerosing skin diseases are addressed in detail. Lichen sclerosus (LS) is a chronic inflammatory dermatosis that results in white plaques with epidermal atrophy and scarring. Immunol. Morphea, also known as localized scleroderma, is a disorder characterized by excessive collagen deposition leading to thickening of the dermis, subcutaneous tissues, or both. J Am Acad Dermatol . Dec 1, 2010 · Histopathological examination of a biopsy confirmed the diagnosis of bullous morphea. Superficial BCC may mimic some inflammatory dermatoses such as psoriasis and eczema. Atrophoderma of Pasini and Pierini and eosinophilic fasciitis are generally viewed as part of the morphea spectrum. GARD can help. Controversy around the name The term scleroderma was probably firstly used by Giovambattista Fantonetti in 1836 to describe a 30-year-old patient with extensive swelling of the skin of the limbs and trunk, accompanied Morphea is an autoimmune disease that causes sclerosis, or scarlike, changes to the skin. The heterogeneity of various forms of SSc as well as the multitude of sclero-derma-like diseases Morphea, also known as localized scleroderma, is a rare fibrosing disorder of the skin and underlying tissues. Treatment of morphea depends on clinical activity, depth of lesion involvement, and extent of disease, and primarily centers around limiting disease activity (8,44 Feb 13, 2023 · Differential diagnosis of morphea types. May 8, 2023 · The approach to the patient with specific skin signs and symptoms is discussed separately. doi: 10. The significance of the disease depends on the extent of the lesions, potential for functional disability or cosmetic disfigurement, and presence or absence of extracutaneous manifestations. Differential Diagnoses. , linear Aug 25, 2022 · Symptoms. Juvenile systemic sclerosis (JSSc) is a chronic multisystem connective tissue disorder characterized by hardening of the skin accompanied by abnormalities Sep 1, 2013 · Lupus profundus is a rare manifestation of cutaneous lupus erythematosus, seen in 1% to 3% of patients. Difficulty and delay in the diagnosis of morphea in children occurs because early morphea can present as nonspecific hypopigmented or hyperpigmented lesions. Morphea (localized scleroderma) is a rare fibrosing disorder of the skin and underlying tissues characterized by skin thickening and hardening due to increased collagen deposition. Original studies and other reports have suggested that DTE is a solitary benign tumor that appears most frequently on the face of young women. Aug 17, 2023 · Linear scleroderma (“linear morphea” or “en coup de sabre”) is one of the five forms of scleroderma and the most common type of localized scleroderma in childhood [ 1 ]. The diagnosis of morphea is mainly based on clinical featur es. Nevertheless a proper review of the constellation of signs and symptoms, with which the patient presents, will assist the astute clinician in differentiating between scleroderma and some of its more common mimics. 3389/fimmu. Evidence-based treatment options of morphea are limited secondary to the rarity of the disease, and the lack of universally used validated outcome measures. Created Date Jan 9, 2020 · differential diagnosis The differential diagnosis of anogenital LSA includes genital lichen planus, vitiligo, LSc, morphea, cicatricial pemphigoid, vulvar intraepithelial neoplasia (VIN), and extramammary Paget's disease. Lichen sclerosus has both genital and extragenital presentations and also goes by the names lichen sclerosus et atrophicus (dermatological literature), balanitis xerotica obliterans (glans penis Feb 13, 2021 · Purpose of review Localized scleroderma (LS), also known as morphea, is a complex and poorly understood disorder in children. The main histologic differential diagnoses are lichen sclerosus and chronic GVHD. Failure to recognize and appropriately treat the affected skin and underlying deep connective tissue can lead to long-term morbidity. The most common clinical differential diagnosis included mycosis fungoides (MF), morphea and contact dermatitis. See full list on dermnetnz. What is the differential diagnosis for morphoea en coup de sabre? Diagnosis can be difficult during the early phase when the morphoea is no more than a pigmented line. 12:656407. Bullae are rarely seen in morphea. Treatment is tailored Differential diagnosis of morphea Inflammatory Phase Infiltrative (Indurated) Phase Burnt-Out Phase Port-wine stain Lipodermatosclerosis Postinflammatory hyperpigmentation Bruising Pretibial myxedema Vitiligo Erythema migrans Panniculitis Trauma-induced fat necrosis/lipoatrophy Chronic graft vs host disease Porphyria cutanea tarda Jul 4, 2022 · Conclusion: We suggest considering scalp morphea in the differential diagnosis of mono-lesional cicatricial alopecia involving the scalp. Histopathologic features included interstitial lymphocytes and histiocytes with dermal mucin. Mar 7, 2022 · The diagnosis of panniculitis can be challenging because different forms of panniculitis may present with similar clinical findings, and many types of panniculitis are rare. In turn, clinicians should be aware that the presence of a bottom heavy pattern of sclerosis and severe inflammation may indicate the patient is at increased risk for morphea Jun 26, 2022 · Differential diagnosis may include residual lesions of postinflammatory hyperpigmentation, Kaposi’s sarcoma, morphea, erythema dyscromicum perstans, and fixed drug eruption. Inimmunofluores-cent studies, immunoglobulin (Ig)G, IgA, IgM, and C3 were reported normal. Vitiligo. Vitiligo is considered one of the most common disorders of dyspigmentation seen in primary care. Morphea is a rare fibrosing disorder of the skin and underlying tissues. Local tissue trauma is a known precipitating factor for morphea lesions, and patients may confuse morphea lesions with trauma Feb 16, 2023 · Morphea is one of the most challenging differential diagnoses of LS by dermoscopy. Nov 14, 2023 · Causes. 1-888-205-2311. The development of morphea can be insidious and subtle, and initial misdiagnosis, particularly by non-dermatologists, occurs frequently [ 80 ]. Morphea lesions have 5 main presentations: (1) circumscribed (few circles on the trunk or limbs); (2 The investigators noted that the clinical differential diagnoses most commonly included BCC, sebaceous hyperplasia, trichoepithelioma (TE), granuloma annulare, scar, and scleroderma. kj of pu so yd di qk xg en ka